The Genetics of Aging

 
Our Guest Editors

Introduction
Modern biological science is at an exciting crossroad. What are the implications for an aging population?
By Richard L. Sprott and Olivia M. Pereira-Smith

Genetic Influences on Late-Life Diseases
Geriatricians have begun to appreciate the importance of genetics to their practices.
By George M. Martin

Evolution of Aging: How Genetic Factors Affect the End of Life
The forces that shape the cycles of maturation, fertility, and death are changing.
By Thomas B. L. Kirkwood

Mortality Dynamics of Aging
Most species do not appear to have a characteristic or "Fixed" lifespan.
By James R. Carey and Debra S. Judge

Animal Models of Aging (Worms to Birds)
Researchers are rapidly closing in on identification of fundamental aging processes.
By Steven N. Austad

Genetics of Human Aging:Swedish Twin Studies
A natural "experiment" for studying the relative importance of genetic and environmental effects.
By Nancy L. Pedersen

Alleles and Aging: The Effects of Different Forms of Genes on Aging and Longevity
With increasingly extensive assessments of all human variation, what prospects come into view for the understanding of aging?
By David Schlessinger

  Replicative Senescence
Cell aging and its impact on the human aging process, with implications for diseases like cancer.
By Olivia M. Pereira-Smith and Michael J. Bertram

Telomere Length, Telomerase, and Aging: Hype, Hope, and Reality
At the center of current discussion of "anti-aging" possibilities.
By Huber R. Warner and Richard J. Hodes

Cell Transplantation and Aging
The technique can be used for study and also to deliver therapeutic gene products to patients.
By Peter J. Hornsby

Genetic Screening in Alzheimer's Disease
Usefulness, limits, and future prospects.
By Rudolph E. Tanzi and Deborah Blacker

Cloning: Techniques and Applications in Human Health
"Dolly" postpartum.
By Calvin B. Harley

Ethical Issues in Genetics and Aging: Diagnosis, Treatment, and Prevention in the Era of Molecular Medicine
Challenges to clinical judgment and the expectations of patients.
By Laurence B. McCullough, Nancy L. Wilson, Jill A. Rhymes, and Thomas A. Teasdale

Implications of Genetic Knowledge for Public Policy
Public reaction ranges from unease to overoptimism.
By John W. Rowe and Margaret Gatz

Books: Dispelling the Most Common Ideas about Why We Age
Review by Gerald Weissmann

 

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